Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer

Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer

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Background & objective: Resistin is a unique hormone secreted from adipocytes.Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic Top Gasket Sensor inflammation plays a role in breast cancer, it seems that resistin may present a molecular link between inflammation and breast carcinogenesis.The aim of this study was to investigate the association of rs1862513 promoter resistin gene variant with breast cancer risk.

Material & Methods: For the purpose of this case-control study, 150 breast cancer and 150 healthy control blood samples were collected.After DNA extraction, genotype determination was performed by PCR-RFLP method.Statistical analysis was done using logistic regression model.

Results: The case and control groups were in Hardy-Weinberg equilibrium.The subjects with GG genotype had increased risk of breast cancer compared to those with CC genotype (OR: 1.9, 95% CI: 1-3.

7, P: 0.04).Also, the G allele Outdoor Chat Set indicated a positive association with breast cancer susceptibility (OR: 1.

4, 95% CI: 1-1.98, P: 0.03).

Conclusion: Results of this study showed possible association of resistin rs1862513 gene variant with breast cancer risk in Iranian women.